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BRD6688，颁础厂:1404562-17-9

BRD6688是一种HDAC抑制剂，其HDAC1,2和3的IC50分别为21 nM，100 nM和11.48μM[1]。与HDAC1相比，HDAC2具有优先结合动力学，延长半衰期6倍（381 min 65分钟）.1 穿越血脑屏障，并已显示在颁碍-辫25神经变性小鼠模型中在情境恐惧条件反射下拯救与辫25诱导的神经变性有关的记忆缺陷.

Formal Name

N-[2-amino-5-(4-pyridinyl)phenyl]-1-pyrrolidinecarboxamide

CAS Number

1404562-17-9

Molecular Formula

C16H18N4O

Formula Weight

282.3

Purity

≥98%

Formulation

A crystalline solid

λmax

315 nm

SMILES

O=C(N1CCCC1)NC2=CC(C3=CC=NC=C3)=CC=C2N

InChI Code

InChI=1S/C16H18N4O/c17-14-4-3-13(12-5-7-18-8-6-12)11-15(14)19-16(21)20-9-1-2-10-20/h3-8,11H,1-2,9-10,17H2,(H,19,21)

InChI Key

YZXBMJVMSBSGMM-UHFFFAOYSA-N

Warning - this product is not for human or veterinary use.

SHIPPING & STORAGE

Storage

-20°C

Shipping

Room temperature in continental US; may vary elsewhere

Stability

≥ 2 years